Vacuum And Hydraulic System of GF Lyophilization Equipment

The moisture in the product can be sublimated quickly only under vacuum to achieve the purpose of drying. The vacuum system of Lyophilization Equipment consists of a freeze-drying box, a condenser, a vacuum valve, a vacuum pump, a vacuum line, and a vacuum measuring component.

The system of Lyophilization Equipment uses a vacuum pump set to form a powerful suction capacity, forming a vacuum in the drying chamber and the condenser, on the one hand, causing the water in the drying chamber to evaporate under vacuum. The vacuum degree of the vacuum system should match the sublimation temperature of the product and the temperature of the condenser. If the degree of vacuum is too high or too low, it is not conducive to sublimation. The vacuum degree of the drying box should be controlled within the set range. Shortening the sublimation cycle of the product, the premise of vacuum control is that the vacuum system itself must have a small leakage rate. The vacuum pump has a large enough power reserve to ensure that the ultimate vacuum is reached.

The hydraulic system of Lyophilization Equipment is a special device that presses the stopper into the bottle mouth at the end of freeze drying. The hydraulic system is located at the top of the drying box and is mainly composed of an electric motor, an oil pump, a check valve, a relief valve, a solenoid valve, a fuel tank, a cylinder and a pipe.

At the end of Lyophilization, the hydraulic plugging system starts to work, and under vacuum conditions, the upper shelf is slowly moved downward to complete the product bottle stoppering task. The hydraulic oil pump station, oil cylinder, etc. are installed in the top of the freeze-drying tank. Under the drive of the hydraulic pump station, the plate layer is lifted up and down in the tank to facilitate the entry and exit of the tank and the cleaning work.

The seal of the lower part of the piston rod of the cylinder uses O-type silicon. The rubber seal ensures that oil will not be contaminated and the drug will be contaminated. The piston uses a YX polyurethane seal. The electromagnetic reversing valve and the hydraulic balancing valve are accurate in signal transmission, and do not slip without vibration. Click gf-machine for in-depth information about GF Machinery.

Drying Box of GF Lyophilization Equipment

The drying oven is one of the important components in the Lyophilization Equipment, and its performance directly affects the performance of the entire Lyophilization Equipment. The freeze-drying box of Lyophilization Equipment is a rectangular or drum type, which can be cooled to about -40C. It can be heated to a vacuum-sealed high and low temperature box body of about +50C.

The bottom of the cabinet is slightly inclined to the rear, and the drain is designed at the lowest point to facilitate drainage.

The freeze-drying of the product is carried out in a dry box, in which there is mainly a shelf on which the product is placed.

The shelves are made of stainless steel with media ducts distributed inside to cool or heat the product.

The laminar components are installed in the freeze-drying box through the bracket, and are driven by the hydraulic piston rod to move up and down, which is convenient for feeding and discharging and cleaning.

The uppermost layer is a temperature-compensated stiffener that ensures the same thermal environment for all products in the box.

The freeze-drying box of Lyophilization Equipment can be installed with the wall of the sterile room. The door is sealed with a special shape silicone rubber strip to seal the door to the same finish as the inside of the freeze-drying box. The material of the door is also made of high-quality stainless steel. It has the same smoothness and flatness as the inside of the freeze-drying box. It can be closely attached to the sealing strip to ensure the sealing under vacuum. The opening angle of the box door of the freeze-drying box is >110 degrees, and the observation window is installed in the center of the door to facilitate the observation of the state of the product in the sterile room.

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Refrigeration System of Lyophilization Equipment

Refrigerant is the working medium in the refrigeration system of Lyophilization Equipment , which is a special kind of liquid with low boiling point, so it is easy to evaporate at low temperature, when it absorbs the surrounding heat during evaporation, the temperature of surrounding objects is lowered Then, the vapor of the liquid is compressed into a high-temperature, high-pressure vapor, which is cooled in the condenser to become a liquid, and then the liquid is depressurized and throttled to absorb heat in the evaporator, so that the temperature of the evaporation portion can be made. Continuously reducing the refrigerant moves the heat from one object to another to achieve a cooling process.

The nature of the refrigerant is directly related to the refrigeration effect, economy, safety and operation management of the refrigeration unit. Therefore, the understanding of the refrigerant property requirements cannot be ignored. For the normal operation of the refrigeration system and to improve efficiency, the following requirements are imposed on the refrigerant of lyophilization equipment:

1.High critical temperature and a low condensing pressure;

2. The latent heat of vaporization and thermal conductivity of the liquid should be large. The specific volume of steam should be small.

3. The boiling point and freezing point are low

4. Density and viscosity, and the adiabatic index should be small.

5. Strong chemical stability, no chemical reaction with lubricant, no corrosive effect on machinery.

6. Harmless to the human body, non-flammable and explosive

7. Low price

Commonly used refrigerants include: ammonia (R717, Freon 12 (R12, Freon 13 (R13, Freon 22 (R22, azeotropic refrigerant R500, azeotropic refrigerant R502, azeotropic refrigerant R503, etc.).

In addition, the brine is an intermediate medium in the Lyophilization Equipment, also known as the second refrigerant, which is mainly used for cooling and heating the shelf in the tank, and transmits the absorbed heat to the refrigerant or absorbs the heat source. The heat is transferred to the shelf to provide the amount of cooling required to freeze the product and the sublimation heat of the product to dry. The purpose of using the brine is to make the shelf temperature uniform.


Zhejiang Guanfeng Food Machinery Co.,Ltd. specializes in lyophilization equipment and
Drying Equipment , If you interested in GuanFeng Machinery, e will spare no effort to provide professional consulting services and solutions to solve user problems. Welcome to consult and purchase our products and services. Contact us

Company: Zhejiang Guanfeng Food Machinery Co.,Ltd.

Add : South industrial park of Dongguan, Shangyu District, Shaoxing City, Zhejiang Province, China 312352

Lyophilization Equipment : https://www.gf-machine.com/product/vacuum-freeze-dryer/